- Received seven consecutive Emmy nominations for Best Actress in a Comedy Series (Malcolm in the Middle (2000)) but never won.
- Studied at Yale University School of Drama, where she was a classmate of Kate Burton.
- Founded the charity "Clothes off our Back" (http://www.clothesoffourback.org) with her ex-husband, Bradley Whitford, in 2002. "Clothes off our Back" runs on-line auctions after major awards shows where celebrities' gowns, tuxedos, and other articles of clothing, are auctioned off. The proceeds go to children's charities such as Cure Autism Now (http://www.cureautismnow.org) and The Children's Defense Fund (http://www.childrensdefense.org/).
- Studied to be a teacher at the University of Wisconsin.
- She and her ex-husband, Bradley Whitford, have three children: Frances Whitford was born in January 1997; George Whitford was born on December 23, 1999 and Mary Louisa Whitford was born on November 25, 2002.
- Her family is Polish.
- With her Malcolm in the Middle (2000) co-star, Erik Per Sullivan, lent her name to the book "Together" and added an afterword. The book aims to educate young people about the importance of livestock to the world; with emphasis on addressing world hunger.
- It was revealed during a segment featuring her ex-husband, Bradley Whitford, on the The Megan Mullally Show (2006) that if she had only one food to eat for the rest of her life, it would be Polish sausage. (October 16, 2006).
- Supporter of Heifer International.
- Actor Daniel von Bargen has coincidentally appeared with husband and wife actors Jane Kaczmarek and Bradley Whitford in four different projects. Along with Kaczmarek, he appeared in Malcolm in the Middle (2000). With Whitford, he was in RoboCop 3 (1993), Philadelphia (1993) and The West Wing (1999).
- Ex-daughter-in-law of Genevieve Smith Whitford.
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