The first Marvel movie based on a character that did not have their own self-titled comic series.
There are no post-credit scenes.
First film to use the Columbia Pictures 100th anniversary opening logo to celebrate the studio's centennial anniversary.
Sydney Sweeney said of this film, "To me, that film was a building block, it's what allowed me to build a relationship with Sony. Without doing Madame Web I wouldn't have a relationship with the decision-makers over there. Everything in my career I do not just for that story, but strategic business decisions. Because I did that, I was able to sell Anyone But You. I was able to get Barbarella."
Sony reportedly had plans for either Andrew Garfield or Tom Holland to appear as Spider-Man, but ultimately cut all references to Spider-Man from the final film.