"Florence Moore," the young girl who was kidnapped, dismembered and murdered, is based on the real case of Marion Parker, a 12-year-old girl who was kidnapped, dismembered and murdered in Los Angeles in December 1927.
Both this show and "Perry Mason" are based in 1930's LA and were released in 2020. They also share the plot points of a kidnapped child being mutilated, as well as the female church leader with a controlling mother. Both were based on actual people from the 30's.
Rory Kinear was Frankenstein's monster in the original Penny Dreadful series with Josh Hartnett and Eva Green.
Paco Cabezas, who directed the last episode of Penny Dreadful (2014), directs the first episode of this series.
The character of Brian, the rocketetry student, appears to be based on Jack Whiteside Parsons. The TV show Strange Angel highlights the life of Jack Parsons.