In the film, the character Amira is Muslim. In real life, Lauren London, the actress who plays Amira, is Ashkenazi Jewish.
David Duchovny's character mentions Xzibit several times through the film. Duchovny and Xzibit had previously acted together in The X Files: I Want to Believe (2008). According to Duchovny in a recent interview, he did not bring this fact to the attention of the creators out of concern that his dialogue would be changed.
Shelley (Julia Louis-Dreyfus) mentions to Amira (Lauren London) that she watched the documentary film Good Hair (2009).
Both London and Nia Long, who plays London's mother in this film, appeared in that documentary as themselves.
Eddie Murphy and Julia Louis-Dreyfus were both cast members on Saturday Night Live (1975) simultaneously from 1982 to 1984. Louis-Dreyfus was also still a cast member when Murphy returned to the show as a guest host on Eddie Murphy/Robert Plant & The Honeydrippers (1984).
Kenya Barris: The man who sits down next to Ezra on the flight to Las Vegas after Akbar gets up and moves to another seat.