- Professional pianist
- Obtained his black belt in karate when he was 9 years old.
- Simon, with his wife Jocelyn Towne, welcomed their first child, daughter Adeline, born May 8, 2012.
- Wife, Jocelyn Towne, had their second child, a son, Wilder Towne Helberg was born on April 23, 2014. The birth was kept secret until June 2014.
- Does remarkable voice imitations of Nicolas Cage and Al Pacino.
- Almost turned down the opportunity to audition for The Big Bang Theory as he was a recurring character on another show already. He decided to audition anyway and after his reading Chuck Lorre said, "Well, actor goes home knowing he killed." Since Simon was not contractually obligated for a second season of the other show, he was cast on Big Bang.
- First cast member of The Big Bang Theory (2007) to receive a Golden Globe Award nomination for feature film, for his performance in Florence Foster Jenkins (2016).
- His paternal grandparents were Polish Jews who survived the Holocaust and came to the U.S. after World War II. His mother is of Russian Jewish and Polish Jewish descent.
- Attended NYU's Tisch School of the Arts where he trained at The Atlantic Theater Company.
- Along with Johnny Galecki the only male cast member of The Big Bang Theory (2007) who is a father as of 2019.
- Curated a night of movies on the Turner Classic Movies channel on November 12, 2013. His film choices were Dr. Strangelove or: How I Learned to Stop Worrying and Love the Bomb (1964), The Party (1968), Brief Encounter (1945), and Modern Romance (1981).
- In two years, he appeared in three different productions about the behind-the-scenes details of the television industry. Those productions are Good Night, and Good Luck. (2005), The TV Set (2006), and Studio 60 on the Sunset Strip (2006).
- His wife Jocelyn is the niece of writer and filmmaker Robert Towne.
- As of 2022, he has appeared in two films that were nominated for the Best Picture Oscar: Good Night, and Good Luck. (2005) and A Serious Man (2009).
- Caught the acting bug after appearing in a high school production of The Children's Hour as the Delivery Boy. Claims he hammed up his three lines to a Jerry Lewis-like level, received an applause break from the audience, and was hooked.
- Son of Sandy Helberg and Harriet B. Helberg.
- Born and raised in Los Angeles, where he resides.
- Is a dedicated liberal Democrat and supported Bernie Sanders in the 2020 elections.
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