- In an interview in Starlog 148 (published November 1989), MacNicol revealed that in the original script for Ghostbusters II (1989), the character of Janosz Poha was a rather lackluster villain called Jason. It was MacNicol who suggested to Ivan Reitman and Harold Ramis to make the art restorer come from Carpathia, linking him to the painting of Vigo. During filming, MacNicol spent a lot of time in his trailer, creating Janosz' origin and accent, as well as a mythology for Carpathia. He even came up with his own vision for a Carpathian flag, which featured a snake stepping on a man.
- His wife, Marsue, runs a not-for-profit foundation that helps inner-city children in Los Angeles.
- Listed as one of twelve "Promising New Actors of 1981" in John Willis' Screen World, Vol. 33.
- His paternal grandfather, originally surnamed "Jonnsen", was of Norwegian descent. Peter's other ancestry is French-Canadian, Irish, Austrian, German, English, Dutch, and Scots-Irish (Northern Irish).
- Is one of four 24 (2001) actors to appear in every episode of the only season in which they appeared. The others are Leslie Hope (Day 1), James Badge Dale (Day 3), and Marisol Nichols (Day 6).
- Surname is pronounced "Mick-nickel".
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